Abstract
RECENT work from this laboratory indicates that intraperitoneal transplantation of isolated pancreatic islets ameliorates the effects of experimental diabetes in rats1. Although the intraperitoneal siting of these islets reduces the hyperglycaemia and polyuria of streptozotocin induced diabetes in these animals, consistently normal values for blood sugar and urine volume are rarely achieved.
Similar content being viewed by others
Article PDF
References
Ballinger, W. F., and Lacy, P. E., Surgery, 72, 175 (1972).
Lacy, P. E., and Kostianovsky, M., Diabetes, 16, 35 (1967).
Scharp, D. W., Kemp, C. B., Knight, M. J., Ballinger, W. F., and Lacy, P. E. (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KEMP, C., KNIGHT, M., SCHARP, D. et al. Transplantation of Isolated Pancreatic Islets into the Portal Vein of Diabetic Rats. Nature 244, 447 (1973). https://doi.org/10.1038/244447a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/244447a0
This article is cited by
-
Total pancreatectomy sequelae and quality of life: results of islet autotransplantation as a possible mitigation strategy
Updates in Surgery (2021)
-
Memory-like Liver Natural Killer Cells are Responsible for Islet Destruction in Secondary Islet Transplantation
Scientific Reports (2019)
-
Brief review: cell replacement therapies to treat type 1 diabetes mellitus
Clinical Diabetes and Endocrinology (2016)
-
Chronic Pancreatitis and Primary Sclerosing Cholangitis—First Report of Intrahepatic Autologous Islet Transplantation
Journal of Gastrointestinal Surgery (2014)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.