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Mechanism of Host Specificity in Malarial Infection

Abstract

INDIVIDUAL species of malaria parasites are highly host specific1 but the mechanisms which determine susceptibility or innate resistance are poorly understood2. In vitro methods for the short-term culture of erythrocytic forms of Plasmodium knowlesi3 and for isolating free merozoite preparations minimally contaminated with host cells4 have provided a basis for studying the ability of serum and of red cells from susceptible and resistant hosts to support the growth and multiplication of this simian parasite.

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References

  1. Garnham, P. C. C., Malaria Parasites (Blackwell, Oxford, 1966).

    Google Scholar 

  2. Zuckerman, A., in Infectious Blood Diseases of Man and Animals (edit. by Weinman, D., and Ristic, M.), 23 (Academic, London, 1968).

    Google Scholar 

  3. Butcher, G. A., and Cohen, S., Parasitology, 62, 309 (1971).

    Article  CAS  PubMed  Google Scholar 

  4. Mitchell, G. H., Butcher, G. A., and Cohen, S., Inter. J. Parasit. (in the press).

  5. Butcher, G. A., and Cohen, S., Immunology, 23, 503 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Cohen, S., Butcher, G. A., and Crandall, R. B., Nature, 223, 368 (1969).

    Article  CAS  ADS  PubMed  Google Scholar 

  7. Butcher, G. A., and Cohen, S., Trans. Roy. Soc. Trop. Med. Hyg., 64, 470 (1970).

    Article  CAS  PubMed  Google Scholar 

  8. Immunity to Parasitic Animals (edit. by Jackson, G. J., Herman, R., and Singer, I.) (Appleton-Century-Crofts, New York, 1970).

  9. Ladda, R., Aikawa, M., and Sprinz, H., J. Parasitol., 55, 633 (1969).

    Article  CAS  PubMed  Google Scholar 

  10. Bang, F. B., in Microbial Pathogenicity in Man and Animals, Symposium 22, Soc. Gen Microbiol., 415 (Cambridge University Press, 1972).

    Google Scholar 

  11. McGhee, R. B., Exp. Parasitol., 30, 267 (1971).

    Article  CAS  PubMed  Google Scholar 

  12. Sherman, I., J. Parasitol., 52, 17 (1966).

    Article  CAS  PubMed  Google Scholar 

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BUTCHER, G., MITCHELL, G. & COHEN, S. Mechanism of Host Specificity in Malarial Infection. Nature 244, 40–42 (1973). https://doi.org/10.1038/244040a0

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