Abstract
IN Parkinson's disease severe decreases occur in striatal L-dopa decarboxylase, putaminal synaptosomal uptake of dopamine, and dopamine and homovanillic acid concentrations in the nigro-striato-pallidal complex1–4. In addition, L-glutamic decarboxylase (GAD) activity is decreased in the caudate nucleus5. The experiments described here were performed to further evaluate this finding and to determine the effect (if any) of L-dopa therapy.
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LLOYD, K., HORNYKIEWICZ, O. L-Glutamic Acid Decarboxylase in Parkinson's Disease: Effect of L-Dopa Therapy. Nature 243, 521–523 (1973). https://doi.org/10.1038/243521a0
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DOI: https://doi.org/10.1038/243521a0
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