Abstract
Surgical removal of the submaxillary glands in adult mice causes a profound drop in the plasma and tissue concentrations of nerve growth factor, and a reduction in the activity of tyrosine hydroxylase within sympathetic ganglia. NGF may be the protein which fulfils the retrograde flow of information from the axon terminal to the cell body.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hendry, I. A., Biochem. J., 128, 1255 (1972).
Levi-Montalcini, R., and Angeletti, P. U., Proceedings of the Fourth Int. Neurochemical Symp. (edit. by Kety and Elks), 362 (1961).
Varon, S., Nomura, J., and Shooter, E., Biochemistra, 7, 1296 (1968).
Hendry, I. A., and Iversen, L. L., Brain Res., 29, 159 (1971).
Black, I. B., Hendry, I. A., and Iversen, L. L., Nature New Biology, 231, 27 (1971).
Black, I. B., Hendry, I. A., and Iversen, L. L., J. Neurochem., 19, 1367 (1972).
Levi-Montalcini, R., Meyer, H., and Hamburger, V., Cancer Res., 14, 49 (1945).
Molinoff, P. B., Brimijoin, S., Weinshilbourn, R., and Axelrod, J., Proc. US Nat. Acad. Sci., 66, 453 (1970).
Mueller, R. A., Thoenen, H., and Axelrod, J., J. Pharmac. Exp. Ther., 169, 74 (1969).
Mueller, R. A., Thoenen, H., and Axelrod, J., Science, 163, 468 (1969).
Mueller, R. A., Thoenen, H., and Axelrod, J., Mol. Pharmac., 5, 463 (1969).
Mueller, R. A., Theonen, H., and Axelrod, J., Eur. J. Pharmac., 10, 51 (1970).
Hamburger, V., J. Exp. Zool., 68, 449 (1934).
Prestige, M. C., J. Embryol. Exp. Morph., 13, 63 (1965).
Prestige, M. C., J. Embryol. Exp. Morph., 17, 453 (1967).
Prestige, M. C., J. Embryol. Exp. Morph., 18, 359 (1967).
Cragg, B. G., Brain Res., 23, 1 (1970).
La Vail, J. M., and La Vail, M. M., Science, 176, 1416 (1972).
Levi-Montalcini, R., and Hamburger, V., J. Exp. Zool., 116, 321 (1951).
Levi-Montalcini, R., and Hamburger, V., J. Exp. Zool., 123, 233 (1953).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HENDRY, I., IVERSEN, L. Reduction in the Concentration of Nerve Growth Factor in Mice after Sialectomy and Castration. Nature 243, 500–504 (1973). https://doi.org/10.1038/243500a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/243500a0
This article is cited by
-
The concept of uptake and retrograde transport of neurotrophic molecules during development: History and present status
Neurochemical Research (1996)
-
Comparative dynamics of retrograde transport of nerve growth factor and horseradish peroxidase in rat lumbar dorsal root ganglia
Journal of Neurocytology (1986)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
