Abstract
NUMEROUS studies in both humans1–3 and animals4 indicate that marihuana and its chief psychoactive constituent, Δ9-tetrahydrocannabinol (Δ9-THC), may have disruptive effects on short term memory. It has been suggested, however, that the memory-disrupting qualities of marihuana in humans may actually be incidental to its effect on normal attentional processes5. Furthermore, interpretation of animal investigations in terms of drug-induced memory disruption may be difficult as Δ9-THC may alter appetitive motivation6. So it is unclear whether performance deficits are a consequence of impaired memory, attention, or motivation.
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References
Tinklenberg, J. R., Melges, F. T., Hollister, L. E., and Gillespie, H. K., Nature, 226, 1171 (1970).
Melges, F. T., Tinklenberg, J. R., Hollister, L. E., and Gillespie, H. K., Science, 168, 1118 (1970).
Dornbush, R. L., Fink, M., and Freedman, A. M., Amer. J. Psychiat., 128, 194 (1971).
Miller, L. L., Drew, W. G., and Wikler, A., Psychopharmacologia (in the press).
Abel, E. L., Science, 173, 1038 (1972).
Manning, F. J., McDonough, J. H., Elsmore, T. F., Suller, C., and Sodetz, F. J., Science, 174, 424 (1971).
MacCorquodale, K., and Meehl, P. E., Modern Learning Theory (Appleton-Century-Crofts, New York, 1954).
Kimball, R. C., Kimball, L. T., and Weaver, H. E., J. Comp. Physiol. Psychol., 46, 274 (1953).
Brown, H., Psychopharmacologia, 21, 294 (1971).
Overton, D. A., in Stimulus Properties of Drugs (edit. by Heistad, G. T., Thompson, T., and Pickens, R.) (Appleton-Century-Crofts, New York, 1970).
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MILLER, L., DREW, W. Impairment of Latent Learning in the Rat by a Marihuana Component. Nature 243, 473–474 (1973). https://doi.org/10.1038/243473a0
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DOI: https://doi.org/10.1038/243473a0
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