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Specific Neutralization of Human Hepatitis Type A in Marmoset Monkeys

Nature volume 243, pages 419–420 (1973)Cite this article

Abstract

THE transmission of human hepatitis type A (infectious hepatitis) to marmoset monkeys, previously reported from this laboratory1–5, has been confirmed by several other laboratories6–9 but questioned by one10,11. To strengthen the case for considering the agents causing experimental hepatitis in marmosets as viruses of human hepatitis type A, and not as latent “marmoset hepatitis viruses” as has been suggested by the dissenting laboratory10,11, it was necessary both to show clearly the lack of induction of disease by normal human serum or plasma and to demonstrate specific neutralization by convalescent human serum of the hepatitis type A agents transmitted from man to marmosets. We describe such neutralization here.

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Author information

Authors and Affiliations

  1. Departments of Microbiology and Medicine, Rush-Presbyterian-St Luke's Medical Center, Chicago, Illinois

    A. W. HOLMES, F. DEINHARDT, L. WOLFE, G. FROESNER, D. PATERSON & B. CASTO

  2. Division of Medicine, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, DC

    M. E. CONRAD

Authors
  1. A. W. HOLMES
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  2. F. DEINHARDT
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  3. L. WOLFE
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  4. G. FROESNER
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  5. D. PATERSON
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  6. B. CASTO
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  7. M. E. CONRAD
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HOLMES, A., DEINHARDT, F., WOLFE, L. et al. Specific Neutralization of Human Hepatitis Type A in Marmoset Monkeys. Nature 243, 419–420 (1973). https://doi.org/10.1038/243419a0

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  • DOI: https://doi.org/10.1038/243419a0

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