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Metabolic Availability of Vitamin C in the Guinea-pig

Nature volume 242, pages 519–521 (1973)Cite this article

Abstract

THE results of studies in which L-gulonolactone-1-14C, the precursor of L-ascorbic acid in the rat, was administered to guinea-pigs showed that the guinea-pig is apparently unable to synthesize vitamin C1–3. This has been attributed to the absence of gulonolactone oxidase from the liver microsomes of the guinea-pig; because this enzyme is the last one in the series for converting glucose to ascorbic acid it completely blocks endogenous synthesis. Synthesis of ascorbic acid has been demonstrated in rats: gulonolactone oxidase is present in their livers4–6. A defect, probably a conditional lethal mutation7, in the gene controlling the synthesis of this enzyme in guinea-pigs produces an inactive enzyme or its complete absence. They are therefore dependent on exogenous vitamin C. This genetic disease has been named hypoascorbemia because of the low levels of ascorbic acid in the blood which are pathognomonic of the condition8. Neither the sex nor the age of the animals in these experiments was stated, and there was no indication of the state of ascorbic acid tissue saturation or of the scorbutic condition of the guinea-pigs.

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References

  1. Burns, J. J., Peyser, P., and Maltz, A., Science, 124, 1148 (1956).

    Article  ADS  CAS  Google Scholar 

  2. Hassan, U., and Lehninger, A. L., J. Biol. Chem., 223, 123 (1956).

    Google Scholar 

  3. Chatterjee, I. B., Chatterjee, G. C., Ghosh, N. C., Ghosh, J. J., and Guha, B. C., Biochemistry, 74, 193 (1960).

    CAS  Google Scholar 

  4. Horowitz, H. H., and King, C. G., J. Biol. Chem., 200, 125 (1953).

    CAS  PubMed  Google Scholar 

  5. Burns, J. J., and Evans, C., J. Biol. Chem., 200, 125 (1953).

    Google Scholar 

  6. Isherwood, F. A., Mapson, L. W., and Chen, Y. T., Biochem. J., 76, 157 (1960).

    Article  CAS  Google Scholar 

  7. Gluecksohn-Waelsch, S., Science, 142, 1269 (1963).

    Article  ADS  CAS  Google Scholar 

  8. Stone, I., Perspect. Biol. Med., 10, 133 (1966).

    Article  CAS  Google Scholar 

  9. Todhunter, E. N., and McMillan, T. J., J. Nutr., 31, 573 (1946).

    Article  CAS  Google Scholar 

  10. Ehme, D. A., Davey, B. L., and Todhunter, E. N., J. Nutr., 58, 281 (1956).

    Article  Google Scholar 

  11. Stubbs, D. W., and McKernan, J. B., Proc. Soc. Exp. Biol., 125, 1326 (1967).

    Article  CAS  Google Scholar 

  12. Sasmal, N., Kar, N. C., Mukherjee, D., and Chatterjee, G. C., Indian J. Biochem., 6, 96 (1969).

    CAS  PubMed  Google Scholar 

  13. Williams, R. J., and Deason, G., Proc. US Nat. Acad. Sci, 57, 1638 (1967).

    Article  ADS  CAS  Google Scholar 

  14. Grollman, A. P., and Lehninger, A. L., Arch. Biochem. Biophys., 69, 458 (1957).

    Article  CAS  Google Scholar 

  15. Burns, J. J., Amer. J. Med., 740 (1959).

  16. Stone, I., Amer. J. Phys. Anthrop., 23, 83 (1965).

    Article  CAS  Google Scholar 

  17. Hughes, R. E., and Hurley, R. J., Brit. J. Nutr., 23, 211 (1969).

    Article  CAS  Google Scholar 

  18. Odumosu, A., and Wilson, C. W. M., Brit. J. Pharmacol., 40, 171P (1970).

    CAS  Google Scholar 

  19. Odumosu, A., and Wilson, C. W. M., Brit. J. Pharmacol., 40, 548P (1970).

    CAS  Google Scholar 

  20. Loh, H. S., and Wilson, C. W. M., Intern. J. Vit. Nutr. Res., 41, 90 (1971).

    CAS  Google Scholar 

  21. Nakajima, Y., Shantha, T. R., and Bourne, G. H., Histochemie, 18, 293 (1969).

    CAS  PubMed  Google Scholar 

  22. Odumosu, A., and Wilson, C. W. M., Brit. J. Pharmacol., 42, 637P (1971).

    CAS  Google Scholar 

  23. Hodges, J. R., and Hotston, R. T., Brit. J. Pharmacol., 40, 740 (1970).

    Article  CAS  Google Scholar 

  24. Odumosu, A., and Wilson, C. W. M., Brit. J. Nutr. Proceedings (in the press).

  25. Cohen, R. B., Proc. Soc. Exp. Biol., 106, 309 (1961).

    Article  CAS  Google Scholar 

  26. Loh, H. S., and Wilson, C. W. M., Intern. J. Vit. Nutr. Res. (1971).

  27. Wilson, C. W. M., Vitamin Documentation, 3 (Hoffman-La Roche, Basle, in the press).

  28. Ginter, E., Bobeck, P., Gerbelova, M., Ondreika, R., and Bilisics, L., Physiologia Biochemoslovencia, 14, 282 (1965).

    CAS  Google Scholar 

  29. Wilson, C. W. M., and Loh, H. S., Irish J. Med. Sci., 2, 396 (1969).

    Article  Google Scholar 

  30. Loh, H. S., and Wilson, C. W. M., Brit. J. Pharmacol., 40, 566P (1970).

    CAS  Google Scholar 

  31. Wilson, C. W. M., Chronobiology: Proc. Intern. Soc. Study of Biological Rhythms (edit. by Scheving, L. E., Halberg, F., and Pauly, J. E.) (Igaku Shoin, Tokyo, in the press).

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Authors and Affiliations

  1. Department of Pharmacology, University of Dublin, Trinity College, Dublin, 2

    ABI ODUMOSU & C. W. M. WILSON

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  1. ABI ODUMOSU
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ODUMOSU, A., WILSON, C. Metabolic Availability of Vitamin C in the Guinea-pig. Nature 242, 519–521 (1973). https://doi.org/10.1038/242519a0

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