Abstract
PANCREATIC transplantation with the aim of treating diabetes mellitus has so far met with little success. Of 23 patients thus treated and reported to the Transplant Registry in 19711, 15 died within 3 months and the longest survived one year. One of the major problems has been to overcome pancreatic exocrine digestion, and pancreatic duct ligation (“Banting pancreas”) before transplantation has been performed. It was shown by Dragstedt2, however, that dogs treated in this way often became diabetic or showed a diabetic glucose tolerance test after several months, probably due to fibrosis and consequent ischaemia of the Islets. Transplantation of the wholegland with its vascular supply is a major undertaking and the problems of thrombosis, leakage and digestion, coupled with immunological rejection, have prevented success so far.
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Change history
01 April 1973
IN the article "Isolation of the Islets of Langerhans for Transplantation" by D. R. Thomas, M. Fox and A. A. Grieve (Nature, 242, 258; 1973) paragraph 1, line 5 and following, should read: "One of the major problems has been to overcome pancreatic exocrine digestion. Pancreatic duct ligation ("Banting pancreas") before transplantation has been performed with this in view.
References
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THOMAS, D., FOX, M. & GRIEVE, A. Biological Sciences: Isolation of the Islets of Langerhans for Transplantation. Nature 242, 258–260 (1973). https://doi.org/10.1038/242258b0
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DOI: https://doi.org/10.1038/242258b0
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