Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

A New Hypothalamic Pathway to the Median Eminence Containing Neurophysin and its Hypertrophy in Sheep with Natural Scrapie

Nature volume 242, pages 63–65 (1973)Cite this article

Abstract

THE hypothalamus is linked to the pituitary by two anatomically distinct neuronal neurosecretory pathways. The first, the hypothalamo-distal neurohypophysial system, commonly termed the supraoptico-neurohypophysial system (SNHS), arises in the “magno-cellular” cell bodies of the supraoptic nuclei (SON) and the paraventricular nuclei (PVN), whence their large axons descend via the internal infundibular zone to the posterior pituitary (Fig. 1)1,2. This system is characterized immunochemically by the neurophysins, the specific carrier-proteins for vasopressin and oxytocin3–6.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Haymaker, W., in The Hypothalamus (edit. by Haymaker, W., Anderson, E., and Nauta, W. J. H.), 219 (Thomas, Springfield, Illinois, 1971).

    Google Scholar 

  2. Szentágothai, J., Progr. Brain Res., 5, 135 (1964).

    Article  Google Scholar 

  3. Dean, C. R., and Hope, D. B., Biochem. J., 106, 565 (1968).

    Article  CAS  Google Scholar 

  4. Kollenberg, M. D., and Hope, D. B., Biochem. J., 106, 557 (1968).

    Article  Google Scholar 

  5. Livett, B. G., Uttenthal, L. O., and Hope, D. B., Phil. Trans. Roy. Soc. (Lond.), B, 261, 371 (1971).

    Article  ADS  CAS  Google Scholar 

  6. Livett, B. G., and Parry, H. B., Brit. J. Pharmacol., 43, 423P (1971).

    CAS  Google Scholar 

  7. Halász, B., in Frontiers in Neuroendocrinology, 1969 (edit. by Ganong, W. F., and Martini, L.), 307 (Oxford University Press, New York, 1969).

    Google Scholar 

  8. Réthelyi, M., and Halász, B., Exp. Brain Res., 11, 145 (1970).

    PubMed  Google Scholar 

  9. Raisman, G., in Brain-Endocrine Interaction; Median Eminence: Structure and Function (edit. by Knigge, K. M., Scott, D. E., and Weindl, A.), 109 (Karger, Basel, 1972).

    Google Scholar 

  10. Fuxe, K., and Hökfelt, T., in Frontiers in Neuroendocrinology, 1969 (edit. by Ganong, W. F., and Martini, L.), 47 (Oxford University Press, New York, 1969).

    Google Scholar 

  11. Fuxe, K., and Hökfelt, T., in Aspects of Neuroendocrinology (edit. by Bargmann, W., and Scharrer, B.), 140 (Springer, Berlin, 1970).

    Google Scholar 

  12. Burgus, R., and Guillemin, R., Ann. Rev. Biochem., 39, 499 (1970).

    Article  CAS  Google Scholar 

  13. Baba, Y., Matsuo, H., and Schally, A. V., Biochem. Biophys. Res. Commun., 44, 459 (1971).

    Article  CAS  Google Scholar 

  14. Yates, F. E., Russell, S. M., and Maran, J. W., Ann. Rev. Physiol., 33, 393 (1971).

    Article  CAS  Google Scholar 

  15. Parry, H. B., Vet. Rec., 69, 43 (1957).

    Google Scholar 

  16. Parry, H. B., Heredity, 17, 75 (1962).

    Article  CAS  Google Scholar 

  17. Beck, E., Daniel, P. M., and Parry, H. B., Brain, 87, 153 (1964).

    Article  CAS  Google Scholar 

  18. Norström, A., Sjöstrand, J., Livett, B. G., Uttenthal, L. O., and Hope, D. B., Biochem. J., 122, 671 (1971).

    Article  Google Scholar 

  19. Livett, B. G., and Parry, H. B., J. Physiol. (in the press, 1972).

  20. Dekanski, J., Brit. J. Pharmac. Chemother., 7, 567 (1952).

    Article  CAS  Google Scholar 

  21. Daniel, P. M., and Prichard, M. M. J., Quart. J. Exp. Physiol., 42, 237 (1957).

    Article  CAS  Google Scholar 

  22. Thorn, N. A., in Aspects of Neuroendocrinology (edit. by Bargmann, W., and Scharrer, B.), 140 (Springer, Berlin, 1970).

    Book  Google Scholar 

  23. Raisman, G., and Field, P. M., in Frontiers in Endocrinology 1971, (edit. by Martini, L., and Ganong, W. F.), 3 (Oxford University Press, New York, 1971).

    Google Scholar 

  24. Ishü, S., Iwata, T., and Kobayashi, H., Endocrinol. Japon., 16, 171 (1969).

    Article  Google Scholar 

  25. Björklund, A., Falk, B., Hromek, F., Owman, C., and West, K. A., Brain Res., 17, 1 (1970).

    Article  Google Scholar 

  26. Clementi, F., Ceccarelli, B., Cerati, E., Demonte, M. L., Felici, M., Motta, M., and Pecile, A., J. Endocrinol., 48, 205 (1970).

    Article  CAS  Google Scholar 

  27. Hamon, M., Javoy, F., Kordon, C., and Glowinski, J., Life Sci., 9 (i), 167 (1970).

    Article  CAS  Google Scholar 

  28. Rinne, U. K., Acta Endocrinol. (Kbh.), 35, 1 (1960).

    CAS  Google Scholar 

  29. Kobayashi, H., Matsui, T., and Ishü, S., Intern. Rev. Cytol., 29, 281 (1970).

    Article  CAS  Google Scholar 

  30. Matsui, T., Endocrinol. Japon., 13, 23 (1966).

    Article  CAS  Google Scholar 

  31. Olivecrona, H., Acta Physiol. Scand., 40, suppl. 136 (1957).

  32. Daniel, P. M., and Prichard, M. M. J., Quart. J. Exp. Physiol., 42, 248 (1957).

    Article  CAS  Google Scholar 

  33. Vierling, R., Anat. Anz., 103, 406 (1956).

    CAS  PubMed  Google Scholar 

  34. Vierling, R., Anat. Anz., 104, 157 (1957).

    CAS  PubMed  Google Scholar 

  35. Moll, J., Z. Zellforsch. Mikroskop. Anat., 46, 686 (1957).

    Article  CAS  Google Scholar 

  36. O'Connor, W. J., Quart. J. Exp. Physiol., 34, 29 (1947).

    Article  CAS  Google Scholar 

  37. Daniel, P. M., and Prichard, M. M. J., Amer. J. Pathol., 34, 433 (1958).

    CAS  Google Scholar 

  38. Daniel, P. M., and Prichard, M. M. J., Brain (in the press).

  39. Stutinsky, F., C. R. Assoc. Anat., 38, 942 (1952).

    Google Scholar 

  40. Moll, J., and De Wied, D., Gen. Comp. Endocrinol., 2, 215 (1962).

    Article  CAS  Google Scholar 

  41. Stutinsky, F., Archs. Anat. Microsc. Morph. Exp., 46, 93 (1957).

    Google Scholar 

  42. Laruelle, M. L., Rev. Neurol., 41, 809 (1934).

    Google Scholar 

  43. Greving, R., Ergebn. Anat. Entro. Gesch., 24, 348 (1923).

    Google Scholar 

  44. Greving, R., Klin. Wschr., 7, 734 (1928).

    Article  Google Scholar 

  45. Laqueur, G. L., J. Comp. Neurol., 101, 543 (1954).

    Article  CAS  Google Scholar 

  46. Ford, H. D., and Kantounis, S., J. Comp. Neurol., 108, 91 (1957).

    Article  CAS  Google Scholar 

  47. Okamoto, S., and Ihara, Y., Anat. Rec., 137, 485 (1960).

    Article  CAS  Google Scholar 

  48. Rinne, U. K., Z. Zellforsch. Mikroskop. Anat., 74, 98 (1966).

    Article  CAS  Google Scholar 

  49. Bisset, G. W., Hilton, S. M., and Poisner, A. M., Proc. Roy. Soc. (Lond.), B, 166, 423 (1967).

    ADS  Google Scholar 

  50. Cross, B. C., Novin, D., and Sundsten, J. W., J. Physiol., 203, 68P (1969).

    CAS  PubMed  Google Scholar 

  51. Monroe, B. G., Z. Zellforsch. Mikroskop. Anat., 76, 405 (1967).

    Article  CAS  Google Scholar 

  52. Knigge, K. M., and Scott, D. E., Amer. J. Anat., 129, 223 (1970).

    Article  CAS  Google Scholar 

  53. Rodríguez, E. M., Z. Zellforsch. Mikroskop. Anat., 93, 182 (1969).

    Article  Google Scholar 

  54. Arko, H., Kivalo, E., and Rinne, U. K., Acta Endocrinol. (Kbh.), 42, 293 (1963).

    Article  Google Scholar 

  55. Akmayev, I. G., Réthelyi, M., and Majorossy, K., Acta Biol. Acad. Sci. Hung., 18, 187 (1967).

    CAS  PubMed  Google Scholar 

  56. Bock, R., and aus der Mühlen, K., Z. Zellforsch. Mikroskop. Anat., 92, 130 (1968).

    Article  CAS  Google Scholar 

  57. Stöhr, P. A., Z. Zellforsch. Mikroskop. Anat., 94, 425 (1969).

    Article  Google Scholar 

  58. Bock, R., and v. Forstner, R., Z. Zellforsch. Mikroskop. Anat., 94, 434 (1969).

    Article  CAS  Google Scholar 

  59. Vernikos-Danellis, J., Endocrinology, 76, 122 (1965).

    Article  CAS  Google Scholar 

  60. Bock, R. V., Forstner, R., aus der Mühlen, K., and Stöhr, P. A., Z. Zellforsch. Mikroskop. Anat., 96, 142 (1969).

    Article  CAS  Google Scholar 

  61. Rinne, U. K., in Aspects of Neuroendocrinology (edit. by Bargmann, W., and Scharrer, B.), 220 (Springer, Berlin, 1970).

    Book  Google Scholar 

  62. Yates, F. E., Russell, S. M., Dallman, M. F., Hedge, G. A., McCann, S. M., and Dhariwal, A. P. S., Endocrinology, 88, 3 (1971).

    Article  CAS  Google Scholar 

  63. Lutz, B., Koch, B., and Mialhe, C., Hormone Metab. Res., 1, 213 (1969).

    Article  CAS  Google Scholar 

  64. Feldman, S., Comforti, N., Chowers, I., and Davidson, J. M., Acta Endocrinol., 63, 405 (1970).

    Article  CAS  Google Scholar 

  65. Parry, H. B., Nature, 185, 441 (1960).

    Article  ADS  CAS  Google Scholar 

  66. Parry, H. B., in Virus Diseases and the Nervous System (edit. by Whitty, C. W. M., Hughes, J. T., and MacCallum, F. O.), 99 (Blackwell, Oxford, 1969).

    Google Scholar 

  67. Draper, G. J., and Parry, H. B., Nature, 195, 670 (1962).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Author notes

  1. B. G. LIVETT

    Present address: Department of Biochemistry, Monash University, Clayton, Victoria, 3168, Australia

Authors and Affiliations

  1. Nuffield Institute for Medical Research, Osler Road, Headington

    H. B. PARRY & B. G. LIVETT

  2. Department of Pharmacology, University of Oxford,

    H. B. PARRY & B. G. LIVETT

Authors
  1. H. B. PARRY
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. G. LIVETT
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

PARRY, H., LIVETT, B. A New Hypothalamic Pathway to the Median Eminence Containing Neurophysin and its Hypertrophy in Sheep with Natural Scrapie. Nature 242, 63–65 (1973). https://doi.org/10.1038/242063a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/242063a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing