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Tetrahydroisoquinoline Alkaloids: in vivo Metabolites of L-Dopa in Man

Nature volume 241, pages 439–443 (1973)Cite this article

Abstract

Tetrahydroisoquinoline alkaloids have been unequivocally demonstrated in vivo for the first time in parkinsonian patients on L-dopa treatment. Their biosynthesis may have a profound bearing on how L-dopa acts.

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Author notes

  1. K. R. HUNTER

    Present address: Plymouth General Hospital, Plumouth

Authors and Affiliations

  1. Bernhard Baron Memorial Research Laboratories and Institute of Obstetrics and Gynaecology, Queen Charlotte's Maternity Hospital, London, W6 0XG

    M. SANDLER & SUSAN BONHAM CARTER

  2. Department of Neurology, University College Hospital, London, WC1E 6BT

    K. R. HUNTER & G. M. STERN

Authors
  1. M. SANDLER
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  2. SUSAN BONHAM CARTER
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  3. K. R. HUNTER
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  4. G. M. STERN
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SANDLER, M., CARTER, S., HUNTER, K. et al. Tetrahydroisoquinoline Alkaloids: in vivo Metabolites of L-Dopa in Man. Nature 241, 439–443 (1973). https://doi.org/10.1038/241439a0

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