Abstract
SEVERE nutritional deficiency in early infancy arrests natural growth and maturation1, resulting in depression of cell number and intellectual function of the brain in animals and man1,2. In experimental animals, nutritional deprivation during gestation, or lactation results in permanent reduction in mature body size and organ weight with a decrease in metabolic efficiency3, even when optimum diets are fed after weaning. These effects are most severe when malnutrition occurs during both gestation and lactation; the most profound changes being in brain and thymus3,4. A similar long term effect of early nutritional deprivation on the developing immunological system has been suggested to occur in man5.
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JOSE, D., STUTMAN, O. & GOOD, R. Long Term Effects on Immune Function of Early Nutritional Deprivation. Nature 241, 57–58 (1973). https://doi.org/10.1038/241057a0
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DOI: https://doi.org/10.1038/241057a0
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