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Acute megakaryoblastic leukemia in children and adolescents, excluding Down's syndrome: improved outcome with intensified induction treatment

Leukemia volume 19, pages 1495–1496 (2005)Cite this article

TO THE EDITOR

Acute megakaryoblastic leukemia (AMKL) occurred in 89 of 1255 (7.1%) of children and adolescents below 18 years of age without Down's syndrome enrolled in the population-based studies AML-BFM 87, 93 and 98. The median age at diagnosis in these 46 male and 43 female subjects with AMKL was 1.5 years (0.3–16.7 years), which was significantly lower than in the total group of children with AML treated between 1/1987 and 12/1999 (n=1255; median age 8.2 years, P<0.001).

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Acknowledgements

This work was supported by grants from the ‘Deutsche Krebshilfe’ (UC, JR), the ‘Deutsche José Carreras Leukämie Stiftung’ (UC, DR) and the ‘Leukemia & Lymphoma Society’ (DR, CL).

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Authors and Affiliations

  1. Department of Pediatric Hematology and Oncology, Hannover Medical School Hanover, Robert-Rössle-Klinik at the HELIOS Klinikum, Berlin

    D Reinhardt

  2. Department of Pediatric Hematology and Oncology, University Children's Hospital, Muenster, Germany

    S Diekamp, C Langebrake, J Ritter, J Stary & U Creutzig

  3. Pediatric Hematology and Oncology, University Hospital Motol, Prague, Czech Republic

    M Dworzak

  4. Children's Cancer Research Institute and St Anna Kinderspital, Vienna, Austria

    A Schrauder & M Zimmermann

  5. Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Bonn, Berlin, Germany

    G Fleischhack

  6. Department of Hematology, Oncology and Tumor Immunology, Charité, Berlin, Germany

    W-D Ludwig

  7. Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Gießen, Berlin

    J Harbott

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  1. D Reinhardt
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Correspondence to D Reinhardt.

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Reinhardt, D., Diekamp, S., Langebrake, C. et al. Acute megakaryoblastic leukemia in children and adolescents, excluding Down's syndrome: improved outcome with intensified induction treatment. Leukemia 19, 1495–1496 (2005). https://doi.org/10.1038/sj.leu.2403815

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