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Therapy-related myelodysplastic syndrome or acute myelogenous leukemia in patients with acute promyelocytic leukemia (APL)

Leukemia volume 16, page 1888 (2002)Cite this article

Latagliata et al1 recently reported a 6.5% incidence of subsequent myelodysplastic syndrome or acute myelogenous leukemia (t-MDS/AML) in patients treated for APL.

From 1980 to 2001, we treated 192 patients with newly diagnosed APL: 40% with chemotherapy without all-trans retinoic acid (ATRA), and 60% with ATRA ± chemotherapy. The median follow-up in the pre-ATRA group is 129 months (range 59 to 262), and 32 weeks (6 to 470 weeks) in the ATRA group. CR rate was 74%, 4% died during consolidation therapy, and 28% relapsed. Median disease-free survival was 278 weeks, and median overall survival was 195 weeks. Patients that have been in CR for more than 2 years can be called potentially cured (59 out 68 have not relapsed with a median follow-up of 4 years).

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References

  1. Latagliata R, Petti MC, Fenu S, Mancini M, Spiriti MA, Breccia M, Brunetti GA, Avvisati G, Lo Coco F, Mandelli F . Therapy-related myelodysplastic syndrome-acute myelogenous leukemia in patients treated for acute promyelocytic leukemia: an emerging problem Blood 2002 99: 822–824

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  2. Bseiso AW, Kantarjian H, Estey E . Myelodysplastic syndromefollowing successful therapy of acute promyelocytic leukemia Leukemia 1997 11: 168–169

    Article  CAS  Google Scholar 

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  1. Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    G Garcia-Manero, HM Kantarjian, S Kornblau & E Estey

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  1. G Garcia-Manero
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  2. HM Kantarjian
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  3. S Kornblau
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  4. E Estey
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Garcia-Manero, G., Kantarjian, H., Kornblau, S. et al. Therapy-related myelodysplastic syndrome or acute myelogenous leukemia in patients with acute promyelocytic leukemia (APL). Leukemia 16, 1888 (2002). https://doi.org/10.1038/sj.leu.2402616

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  • DOI: https://doi.org/10.1038/sj.leu.2402616

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