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Acute Leukemia Forum 2000, Advances and Controversies in the Therapy of Acute Myelogenous Leukemia

Potential for therapy with AML-derived dendritic cells

Leukemia volume 15, pages 668–669 (2001)Cite this article

A number of studies suggest that a cellular immunotherapy is already an established and curative therapy for acute myelogenous leukemia (AML). Recent data from nonablative allogeneic stem cell transplants for AML at MD Anderson demonstrate that there is a graft-versus-leukemia affect associated with graft-versus-host disease in patients who have allografts for this disease. However, graft-versus-host disease is associated with substantial toxicity. Attempts have therefore been made to improve immunotherapeutic approaches. One approach has been to take myeloid leukemia cells and culture them in the presence of cytokines to generate dendritic cells. These dendritic cells are then able to stimulate autologous and allogeneic cytotoxic T cells.

Dendritic cells exist in all tissues. They take up antigen, migrate to regional lymph nodes, and initiate primary T cell-mediated immunity. They have abundant expression of core stimulatory molecules, CD80 and CD86, other adhesion molecules, and abundant surface class 1 and 2 major histocompatibility complex (MHC) protein. A number of studies are ongoing to utilize dendritic cells to present peptide antigens.

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References

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Authors and Affiliations

  1. Penn State College of Medicine, Milton S Hershey Medical Center, Hershey, PA, USA

    D Claxton

  2. The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    A Choudhury

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  1. D Claxton
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  2. A Choudhury
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Claxton, D., Choudhury, A. Potential for therapy with AML-derived dendritic cells. Leukemia 15, 668–669 (2001). https://doi.org/10.1038/sj.leu.2402056

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  • DOI: https://doi.org/10.1038/sj.leu.2402056

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