Abstract
We present the clinicopathologic findings and survival data on 10 patients with acute lymphoblastic leukemia (ALL) and a rare t(8;14)(q11.2;q32). There were five male and five female patients, nine Caucasians and one Black, aged 4–17 (median 10.9) years. Three had Down syndrome. Eight (80%) patients had a white blood cell (WBC) count <50 × 109/l at presentation. No patient had central nervous system involvement or a mediastinal mass. Two patients had concurrent splenomegaly and hepatomegaly. Adenopathy was absent in four, minimal in three, moderate in one and prominent in two patients. All eight cases where immunophenotyping was performed by flow cytometry showed a B-precursor phenotype with expression of CD10 (CALLA). Only one case exhibited t(8;14)(q11.2;q32) as the sole karyotypic abnormality. Three patients were classified as standard-risk and seven high-risk by NCI (National Cancer Institute) consensus risk group categories. All patients achieved complete remission and seven patients were in complete continuous remission (CCR) after chemotherapy designed for B-precursor ALL. Three patients relapsed after 23.5, 31.3 and 32.1 months of EFS; the first patient also had t(9;22)(q34;q11), the second had a WBC count of 126 × 109/l at presentation while the third patient had no high risk features except for age 10 years. Thus, from our data, the t(8;14)(q11.2;q32) does not appear to confer an increased risk of relapse. Further observations are needed to confirm this conclusion.
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References
Williams DL, Harris A, Williams KJ, Brosius MJ, Lemonds W . A direct bone marrow chromosome technique for acute lymphoblastic leukemia Cancer Genet Cytogenet 1984 13: 239–257
Pui C-H, Williams DL, Roberson PK, Raimondi SC, Behm SH, Lewis SH, Rivera GK, Kalwinsky DK, Abromowitch M, Crist WM . Correlation of karyotype and immunophenotype in childhood acute lymphoblastic leukemia J Clin Oncol 1988 6: 56–61
Bloomfield CD, Goldman AI, Alimena G, Berger R, Borgstrom HG, Brandt L, Catovsky D, Chapelle ADL, Dewald GW, Garson OM, Garwicz S, Golomb HM, Hossfeld DK, Lawler SD, Mitelman F, Nilsson P, Pierre RV, Philip P, Prigogina E, Rowley JD, Sakurai M, Sandberg AA, Secker-Walker LM, Tricot G, Berghe HVD, Orshoven AV, Vuopio P, Whang-Peng J . Chromosome abnormalities identify high-risk and low-risk patients with acute lymphoblastic leukemia Blood 1986 67: 415–420
Harris MB, Shuster JJ, Carroll A, Look AT, Borowitz MJ, Crist WM, Nitschke R, Pullen J, Steuber CP, Land VJ . Trisomy of leukemic cell chromosomes 4 and 10 identifies children with B-progenitor cell acute lymphoblastic leukemia with a very low risk of treatment failure: a Pediatric Oncology Group study Blood 1992 79: 3316–3324
Crist WM, Carroll AJ, Shuster JJ, Behn FG, Whitehead M, Vietti TJ, Look AT, Mahoney D, Ragab A, Pullen DJ, Land VJ . Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with t(1;19)(q23;p13): a Pediatric Oncology Group study Blood 1990 76: 117–122
Bloomfield CD, Secker-Walker LM, Goldman AI, Berghe HVD, Chapelle ADL, Ruutu T, Alimena G, Garson OM, Golomb HM, Rowley JD, Kaneko Y, Whang-Peng J, Prigogina E, Philip P, Sandberg AA, Lawler SD, Mitelman F . Six-year follow-up of the clinical significance of karyotype in acute lymphoblastic leukemia Cancer Genet Cytogenet 1989 40: 171–185
Third International Workshop on Chromosomes in Leukemia . Chromosomal abnormalities and their clinical significance in acute lymphoblastic leukemia Cancer Res 1983 43: 868–873
Pui C-H, Crist W, Look A . Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia Blood 1990 76: 1449–1463
Kardon NB, Slepowitz G, Kochen JA . Childhood acute lymphoblastic leukemia associated with an unusual 8;14 translocation Cancer Genet Cytogenet 1982 6: 339–343
Carroll AJ, Raimondi SC, Borowitz MJ, Amylon MD, Rivera G, Pullen DJ, Crist WM . A new nonrandom 8;14 translocation in children with acute lymphoblastic leukemia Am J Hum Genet 1988 43: A21: (Abstr.)
Hayashi Y, Pui C-H, Behm FG, Fuchs AH, Raimondi SC, Kitchingman GR, Mirro J, Williams DL . 14q32 translocations are associated with mixed-lineage expression in childhood acute leukemia Blood 1990 76: 150–156
Wodzinski MA, Watmore AE, Lilleyman JS, Potter AM . Chromosomes in childhood acute lymphoblastic leukemia: karyotypic patterns in disease subtypes J Clin Pathol 1991 44: 48–51
Testoni N, Zaccaria A, Martinelli G, Pelliconi S, Buzzi M, Farabegoli P, Panzica G, Tura S . t(8;14)(q11;q32) in acute lymphoid leukemia: description of two cases Cancer Genet Cytogenet 1993 67: 55–58
Secker-Walker LM, Hawkins JM, Prentice HG, Mackie PH, Heerema NA, Provisor AJ . Two Down syndrome patients with an acquired translocation, t(8;14)(q11;q32), in early B-lineage acute lymphoblastic leukemia Cancer Genet Cytogenet 1993 70: 148–150
Lee AC, Chan LC, Kwong KW . Down syndrome, acute lymphoblastic leukemia, and t(8;14)(q11;q32) (letter) Cancer Genet Cytogenet 1996 88: 92
Murphy SB, Bowman WP, Abromowitch M, Mirro J, Ochs J, Rivera G, Pui CH, Fairclough D, Berard CW . Results of treatment of advanced Burkitt's lymphoma and B-cell (sIG+) acute lymphoblastic leukemia with high dose fractionated cyclophosphamide and coordinated high dose methotrexate and cytarabine J Clin Oncol 1986 4: 1732–1739
Smith M . Towards a more uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia (ALL) Am Soc Clin Oncol Educational Book. Dallas, TX 1994 pp 124–130
Morris CM, Bowen J, Fitzgerald PH . Localization of human c-mos to chromosome band 8q11 in leukemic cells with the t(8;21)(q22;q22) Hum Genet 1989 81: 339–342
Hesketh R . The Oncogene and Tumor Suppressor Gene: Facts Book Academic Press, Harcourt Brace: New York 1997
Li C-CH, Chen E, O'Connell CD, Longo DL . Detection of c-mos protooncogene expression in human cells Oncogene 1993 8: 1685–1691
Posada J, Yew N, Ahn NG, Woude GFV, Cooper JA . Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro Mol Cell Biol 1993 13: 2546–2553
Huang CF, Ferrell JE . Dependence of Mos-induced Cdc2 activation on MAP kinase function in a cell-free system EMBO J 1996 15: 2169–2173
Stenman G, Sahlin P, Mark J, Landys D . Structural alterations of the c-mos locus in benign pleomorphic adenomas with chromosome abnormalities of 8q12 Oncogene 1991 6: 1105–1108
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Kaleem, Z., Shuster, J., Carroll, A. et al. Acute lymphoblastic leukemia with an unusual t(8;14)(q11.2;q32): a Pediatric Oncology Group study. Leukemia 14, 238–240 (2000). https://doi.org/10.1038/sj.leu.2401675
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DOI: https://doi.org/10.1038/sj.leu.2401675