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Etoposide-related acute promyelocytic leukemia

Leukemia volumeĀ 12,Ā pages 1171ā€“1175 (1998)Cite this article

Abstract

The development of therapy-related acute myeloid leukemia (t-AML) has become a growing concern over the past decade, because of the increase in the percentage of long-term survivors of primary malignancy. We reviewed 17 cases with etoposide-related acute promyelocytic leukemia (APL) reported in the literature. The close association between treatment with etoposide for Langerhans cell histiocytosis (LCH) and the development of etoposide-related APL was demonstrated among Japanese and Italians. Our data on the breakpoints (b/ps) of the PML and RARĪ± genes are presented. It is suggested that chromatin structure might be more important than specific consensus sequence in the distribution of b/ps in etoposide-related APL.

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Authors and Affiliations

  1. Department of Pediatrics, Nagoya University School of Medicine, Japan

    K Kudo,Ā S NumataĀ &Ā K Horibe

  2. Department of Infectious Diseases, Nagoya University Hospital, Nagoya, Japan

    H Yoshida,Ā H KiyoiĀ &Ā T Naoe

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  1. K Kudo
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  2. H Yoshida
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  3. H Kiyoi
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  4. S Numata
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  5. K Horibe
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  6. T Naoe
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Kudo, K., Yoshida, H., Kiyoi, H. et al. Etoposide-related acute promyelocytic leukemia. Leukemia 12, 1171ā€“1175 (1998). https://doi.org/10.1038/sj.leu.2401089

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  • DOI: https://doi.org/10.1038/sj.leu.2401089

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