Abstract
The transformation of normal hematopoietic cells to leukemic cells requires cells to acquire two intrinsic changes. These are the acquisition by some method of autocrine growth stimulation and a perturbation of differentiation commitment leading to abnormal levels of self-generation. Hematopoietic regulator action can be involved to produce or facilitate both these changes but the same regulators can also suppress some leukemic populations by enforced differentiation commitment.
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Metcalf, D. The Charlotte Friend Memorial Lecture. The role of hematopoietic growth factors in the development and suppression of myeloid leukemias. Leukemia 11, 1599–1604 (1997). https://doi.org/10.1038/sj.leu.2400831
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DOI: https://doi.org/10.1038/sj.leu.2400831
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