Abstract
The well-known family of NF-κ B/Rel transcription factors is a central regulator of growth, differentiation and apoptosis in hematopoietic cell lineages. There is increasing evidence for their role in malignant transformation, especially in lymphomas. To study the possible involvement of NF-κB/Rel genes in the development of pediatric acute lymphoblastic leukemia (ALL), DNA samples from 140 patients were examined by Southern blot analysis. All samples revealed germline configuration of nfkb2, c-rel, and bcl3, indicating that structural alterations of these members of the NF-κ B/Rel family are extremely rare, if existing at all in childhood ALL.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Liptay, S., Seriu, T., Bartram, C. et al. Germline configuration of nfkb2, c-rel and bcl3 in childhood acute lymphoblastic leukemia (ALL). Leukemia 11, 1364–1366 (1997). https://doi.org/10.1038/sj.leu.2400778
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/sj.leu.2400778
Keywords
This article is cited by
-
Nuclear localisation of nuclear factor-kappaB transcription factors in prostate cancer: an immunohistochemical study
British Journal of Cancer (2005)
-
Molecular Pharmacodynamics in Childhood Leukemia
International Journal of Hematology (2003)
-
Transcription factor NF-κB is constitutively activated in acute lymphoblastic leukemia cells
Leukemia (2000)