Abstract
THE development of cell fusion techniques has presented new possibilities in the study of nucleocytoplasmic relationships1. Where specific cell products can be traced, regulation of their synthesis by the heterokaryon nuclei can be elucidated. The switch from tadpole to adult frog haemoglobin in the bullfrog, Rana catesbeiana2,3, involves a change from synthesis of one predominant polypeptide subunit to another, or the inhibition of one structural gene and activation of the other (M. R., in preparation). I have fused tadpole and frog erythrocytes and followed the haemoglobin types synthesized by the heterokaryons.
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ROSENBERG, M. Fusion of Frog and Tadpole Erythrocytes. Nature 239, 520–522 (1972). https://doi.org/10.1038/239520b0
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DOI: https://doi.org/10.1038/239520b0
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