Abstract
THE efflux of the 22Na at 37° C from normal human red blood cells incubated with 22Na into media containing different concentrations of potassium and lithium has been studied. Lithium at concentrations of 3 mM and 6 mM causes a significant stimulation of efflux, when the concentration of potassium is zero or 2 mM, but the effect of lithium is not apparent in the presence of 6 mM potassium which itself causes a big stimulation. This stimulation of the sodium pump by extracellular lithium may explain observations of a low intracellular sodium concentration under such conditions. It may be relevant to the prophylactic action of lithium salts in manic-depressive disease.
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GLEN, A., BRADBURY, M. & WILSON, J. Stimulation of the Sodium Pump in the Red Blood Cell by Lithium and Potassium. Nature 239, 399–401 (1972). https://doi.org/10.1038/239399a0
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DOI: https://doi.org/10.1038/239399a0
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