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Opposite Effects of L-Dopa and 5-HTP on Spinal Sympathetic Reflexes

Abstract

HISTOCHEMICAL mapping of monoamine-containing neurones in the spinal cord has established the course and terminations of abundant descending neurones that contain either noradrenaline (NA) or 5-hydroxytryptamine (5-HT). Although these neurones terminate throughout the spinal grey matter, the intermediolateral columns receive the most dense terminations of both NA and 5-HT neurones that appear to make intimate synaptic contact with sympathetic preganglionic neurones1,2. The possibility that sympathetic outflow is influenced by these monoaminergic neurones is strengthened by the locations of their cell bodies in areas of the caudal medulla oblongata that are involved in central vasomotor control3.

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HARE, B., NEUMAYR, R. & FRANZ, D. Opposite Effects of L-Dopa and 5-HTP on Spinal Sympathetic Reflexes. Nature 239, 336–337 (1972). https://doi.org/10.1038/239336a0

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