Abstract
THE belief that optimal competitive neuromuscular blockade occurs with compounds having two quaternary centres 12.5 Å apart1,2 has been progressively weakened by the demonstration3 that (+)-tubocurarine is a monoquaternary compound, by the X-ray studies4 on a potent curarizing steroidal derivative* in which the interjacence is 11.1 Å and by the even closer centres (9.7 Å) in the similarly active diallyl bis-nortoxiferine. Further evidence that an interquaternary distance of 12.5 Å is not critical in competitive neuromuscular blocking drugs is provided by the novel 1,1′-azobis-arylimidazo[1,2-a]pyridinium bromides, in which this interjacence is close to 7.5 Å.
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POINTER, D., WILFORD, J. & BISHOP, D. Biological Sciences: Crystal Structure of a Novel Curariform Agent. Nature 239, 332–333 (1972). https://doi.org/10.1038/239332a0
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DOI: https://doi.org/10.1038/239332a0
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