Abstract
IN chimaeras (for example, embryo-fusion chimaeras in mice) or in females heterozygous for X-linked markers (according to the single-active-X hypothesis), two genetically distinct cell populations co-exist in the same individual. For characters which are cell-autonomous, so that the genotype of individual cells can be deduced by observing the cell itself (for example, the pigmented layer of the retina) or a cell product (for example, pigment in hairs; electrophoretic enzyme variants), one can estimate the proportion of cells belonging to each population in any given organ or tissue.
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References
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MCLAREN, A. Biological Sciences: Numerology of Development. Nature 239, 274–276 (1972). https://doi.org/10.1038/239274a0
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DOI: https://doi.org/10.1038/239274a0
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