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Differential Staining Patterns of Human Chromosomes treated with Potassium Permanganate

Abstract

THE permanganate ion has occasionally been used in histology and histochemistry to demonstrate particular components in animal tissues1,2. In electron microscopy, potassium permanganate has been used in some fixatives3 and as a stain4. Permanganate oxidation has also been used to chemically degrade DNA5 and under certain mild conditions to oxidize preferentially pyrimidine residues, especially the thymine residue of heat-denatured DNA with a small strand break6,7.

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UTAKOJI, T. Differential Staining Patterns of Human Chromosomes treated with Potassium Permanganate. Nature 239, 168–170 (1972). https://doi.org/10.1038/239168a0

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