Abstract
HYCANTHONE methanesulphonate, a drug believed to be effective in the treatment of schistosomiasis, is being administered to many individuals in Africa and Brazil during extensive field studies (therapeutic doses are 3–4 mg/kg). Studies have shown that hycanthone is mutagenic in bacterial1 and mammalian cell2 systems. This demonstrated mutagenic activity, plus the daily administration of the drug to large numbers of people, suggested that hycanthone methanesulphonate be evaluated for teratogenic capabilities.
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References
Hartman, P. E., Levine, K., Hartman, Z., and Berger, H., Science, 172, 1058 (1971).
Clive, D., Flamm, W. G., and Machesko, M. R., Mutation Res., 14, 262 (1972).
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MOORE, J. Teratogenicity of Hycanthone in Mice. Nature 239, 107–109 (1972). https://doi.org/10.1038/239107a0
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DOI: https://doi.org/10.1038/239107a0
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