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Requirement for Θ-Bearing Cells in Lymphocytic Choriomeningitis Virus-induced Central Nervous System Disease

Nature volume 238, pages 335–337 (1972)Cite this article

Abstract

THE immunopathological basis of the acutely fatal convulsive central nervous system (CNS) disease produced in adult mice following cerebral infection with lymphocytic Choriomeningitis (LCM) virus is well established1. Thus, a variety of immuno-suppressive treatments, given to adult mice inoculated intracerebrally with a potentially lethal dose of virus, produce a transient or permanent ablation of both the histological and clinical correlates of LCM. Permanently protected mice usually maintain high virus concentrations in their brains and blood for life2,3, presenting a picture which, on virological grounds, is strikingly similar to the lifelong virus carrier state arising in mice inoculated with LCM virus shortly after birth3,4.

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Authors and Affiliations

  1. Departments of Epidemiology and Ophthalmology, Schools of Hygiene and Medicine, Johns Hopkins University, Baltimore, Maryland, 21205

    G. A. COLE, N. NATHANSON & R. A. PRENDERGAST

Authors
  1. G. A. COLE
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  2. N. NATHANSON
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  3. R. A. PRENDERGAST
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COLE, G., NATHANSON, N. & PRENDERGAST, R. Requirement for Θ-Bearing Cells in Lymphocytic Choriomeningitis Virus-induced Central Nervous System Disease. Nature 238, 335–337 (1972). https://doi.org/10.1038/238335a0

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  • DOI: https://doi.org/10.1038/238335a0

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