Abstract
Atropine, para-chlorophenylalanine and indomethacin modify some effects of morphine withdrawal in the rat. Factors determining the intensity and even the direction of this modification include the particular withdrawal effect observed and the time in the course of dependence when the modifying drug is given. These findings suggest that morphine dependence is multipartite and that acetylcholine, 5-hydroxytryptamine and prostaglandin(s) play intimate parts in various elements of dependence.
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COLLIER, H., FRANCIS, D. & SCHNEIDER, C. Modification of Morphine Withdrawal by Drugs interacting with Humoral Mechanisms: Some Contradictions and their Interpretation. Nature 237, 220–223 (1972). https://doi.org/10.1038/237220a0
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DOI: https://doi.org/10.1038/237220a0
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