Abstract
IT has been suggested1 that during the interaction of acetylcholine (ACh) with the cholinergic receptor (ChR) each elementary ionic channel of the postsynaptic membrane (PSM) becomes active, that is accessible for K+ and Na+ ions, for such short a time that the equilibrium potential (Ep) of PSM is determined by a current which is far from stationary. This suggestion—the hypothesis2 of “transient state of ionic channel”—arose from the finding3,4 that Ep of the PSM is described by in wide range of external concentrations of K+ and Na+ ions, where [K]o, [Na]o, and [K]i, [Na]i are the external and internal K+ and Na+ concentrations respectively; ΔgK and ΔgNa are PSM conductances for K+ and Na+ ions respectively; R is the gas constant, F is the Faraday number and T is theabsolute temperature.
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References
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BREGESTOVSKI, P., CHAILACHJAN, L., DUNIN-BARKOVSKI, V. et al. Effect of Temperature on the Equilibrium Endplate Potential. Nature 236, 453–454 (1972). https://doi.org/10.1038/236453a0
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DOI: https://doi.org/10.1038/236453a0
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