Abstract
Calculations of the energy required to form misaligned transition states in the confines of a solvent cage indicate that many reactions could be very considerably catalysed by precise alignment (orbital steering) in enzyme active sites.
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References
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HOARE, D. Significance of Molecular Alignment and Orbital Steering in Mechanisms for Enzymatic Catalysis. Nature 236, 437–440 (1972). https://doi.org/10.1038/236437a0
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DOI: https://doi.org/10.1038/236437a0
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