Abstract
Cis platinum (II) diammino-dichloride, cis Pt(II)(NH3)2Cl2 (A), is very effective against sarcoma 180 and leukaemia L 1210 in mice1,2 as well as Dunning ascites leukaemia and Walker 256 carcinosarcoma tumours in rats3. This and related compounds also reversibly inhibit cell division and induce cell elongation in E. coli B4,5. At a concentration below 5 µ, cis Pt(II)(NH3)2Cl2 selectively inhibits DNA synthesis in human amnion AV3 cells6, and there is a correlation between the relative effectiveness of a series of compounds and their capacity to inhibit DNA synthesis6. Support for the suggestion that in this cell line the effective platinum compounds acted by binding directly to DNA was obtained by Howie and Gale7. They found that DNA synthesis was selectively and persistently inhibited in Ehrlich ascites tumour cells removed from rats up to 4 days after treatment with a single injection of 10 mg/kg of A.
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ROBERTS, J., PASCOE, J. Cross-linking of Complementary Strands of DNA in Mammalian Cells by Antitumour Platinum Compounds. Nature 235, 282–284 (1972). https://doi.org/10.1038/235282a0
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DOI: https://doi.org/10.1038/235282a0
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