Abstract
A model is proposed for clonal proliferation and antibody production of B lymphocytes. It suggests that changes in the B cell surface due to specific antigen binding are detected by T lymphocytes, which then stimulate the B cell to proliferate.
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References
Parrott, D. M. V., de Sousa, M. A. B., and East, J., J. Exp. Med., 123, 191 (1966).
Raff, M. C., Transpl. Rev., 6, 52 (1971).
Miller, J. F. A. P., and Mitchell, G. F. ; Davies, A. J. S. ; Claman, H. N., and Chaperon, E. A. ; Taylor, R. B., in Transpl. Rev., 1 (1969).
Mitchison, N. A., Rajewsky, K., and Taylor, R. B., in Developmental Aspects of Antibody Formation and Structure (edit. by Šterzl, J., and Řiha, L.), 547 (Academia Publishing House, Prague, 1970).
Raff, M. C., Nature, 226, 1257 (1970).
Taylor, R. B., and Iverson, G. M., Proc. Roy. Soc., B, 176, 393 (1971).
Miller, J. F. A. P., in Cell Interactions and Receptor Antibodies in Immune Responses (edit. by Mákelá, O., Cross, A., and Kosunen, T. U.), 293 (Academic Press, New York, 1971).
Askonas, B. A., Williamson, A. R., and Wright, B. E. G., Proc. US Nat. Acad. Sci., 67, 1398 (1970).
Mitchison, N. A., Europ. J. Immunol., 1, 10 (1971).
Dummonde, D. C., Wolstencroft, R. A., Panayi, G. S., Matthew, M., Morley, J., and Howson, W. T., Nature, 224, 38 (1969).
Hartmann, K.-U., J. Exp. Med., 132, 1267 (1970).
Katz, D. H., Paul, W. E., Goidl, E. A., and Benacceraf, B., J. Exp. Med., 133, 169 (1971).
Burnet, F. M., Immunological Surveillance (Pergamon, Oxford, 1970).
Jimenez, L., Bloom, B. R., Blume, M. R., and Oettgen, H. F., J. Exp. Med., 133, 740 (1971).
Roitt, I. M., Torrigiani, G., Greaves, M. F., Brostoff, J., and Playfair, J. H. L., Lancet, ii, 367 (1969).
Walters, C. S., and Wigzell, H., J. Exp. Med., 132, 1233 (1970).
Humphrey, J. H., Roelants, G., and Willcox, N., in Cell Interactions and Receptor Antibodies in Immune Responses, 123 (Academic Press, New York, 1971).
Baker, Ph. J., Stashak, Ph. W., Amsbaugh, D. F., Prescott, B., and Barth, R. F., J. Immunol., 105, 1581 (1970).
Herzenberg, L. A., J. Cell. Physiol., 76, 303 (1970).
Allison, A. C., Denman, A. M., and Barnes, R. D., Lancet, ii, 135 (1971).
McCullagh, P. J., J. Exp. Med., 132, 916 (1970).
Oliner, H., Schwartz, R., and Dameshek, W., Blood, 17, 20 (1961).
Williamson, A. R., Europ. J. Immunol. (in the press).
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KRETH, H., WILLIAMSON, A. Cell Surveillance Model for Lymphocyte Cooperation. Nature 234, 454–456 (1971). https://doi.org/10.1038/234454a0
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DOI: https://doi.org/10.1038/234454a0
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