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Transformation of Human Leucocytes by Throat Washing from Infectious Mononucleosis Patients

Nature volume 234, pages 359–360 (1971)Cite this article

Abstract

A SIMPLIFIED procedure for studying induced transformation of human leucocytes in vitro.1 utilizes umbilical cord blood leucocytes which are easily obtained and do not transform spontaneously. When treated with cell-free filtrates from lymphoblastoid cell lines of a mononucleosis patient and three healthy persons, cord blood leucocytes were transformed to rapidly and persistently multiplying lymphoblasts2,3. Chemical carcinogens and ionizing radiation were ineffective2. In a long term search for transforming agents in the human environment, we have studied numerous agents including the secretion from upper respiratory tract of mononucleosis patients. We found that their secretion contained transforming activity.

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References

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Authors and Affiliations

  1. Department of Medical Microbiology, University of California, Davis, California, 95616

    R. SHIHMAN CHANG & H. DEAN GOLDEN

Authors
  1. R. SHIHMAN CHANG
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  2. H. DEAN GOLDEN
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CHANG, R., GOLDEN, H. Transformation of Human Leucocytes by Throat Washing from Infectious Mononucleosis Patients. Nature 234, 359–360 (1971). https://doi.org/10.1038/234359a0

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