Abstract
A SIMPLIFIED procedure for studying induced transformation of human leucocytes in vitro.1 utilizes umbilical cord blood leucocytes which are easily obtained and do not transform spontaneously. When treated with cell-free filtrates from lymphoblastoid cell lines of a mononucleosis patient and three healthy persons, cord blood leucocytes were transformed to rapidly and persistently multiplying lymphoblasts2,3. Chemical carcinogens and ionizing radiation were ineffective2. In a long term search for transforming agents in the human environment, we have studied numerous agents including the secretion from upper respiratory tract of mononucleosis patients. We found that their secretion contained transforming activity.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Chang, R. S., Hsieh, M.-W., and Blankenship, W., J. Nat. Cancer Inst., 47, 469 (1971).
Chang, R. S., Hsieh, M.-W., and Blankenship, W., J. Nat. Cancer Inst., 47, 479 (1971).
Chang, R. S., Nature New Biology, 233, 124 (1971).
Hoagland, R. J., Infectious Mononucleosis (Grune and Stratton, New York, 1967).
Henle, G., and Heble, W., J. Bact., 91, 1248 (1966).
Pope, J. H., Horne, M. K., and Scott, W., Intern. J. Cancer, 3, 857 (1968).
Pope, J. H., Horne, M. K., and Scott, W., Intern. J. Cancer, 4, 255 (1969).
Gerber, P., Whang-Peng, J., and Monroe, J. H., Proc. US Nat. Acad. Sci., 63, 740 (1969).
Golden, H. D., Chang, R. S., Lou, J., and Cooper, T. Y., J. Infect. Dis. (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CHANG, R., GOLDEN, H. Transformation of Human Leucocytes by Throat Washing from Infectious Mononucleosis Patients. Nature 234, 359–360 (1971). https://doi.org/10.1038/234359a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/234359a0
This article is cited by
-
The ecology and pathology of Epstein‐Barr virus
Immunology & Cell Biology (1995)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.