Abstract
THE antitumour properties of certain inorganic platinum compounds in mice were first reported by Rosenberg et al.1. Of thirty-four compounds tested the cis-platinum (ii) diamminodichloride and the cis-platinum (iv) diamminotetrachloride had the highest activity, producing marked regression of large solid sarcoma 180 tumours in 63–100% of mice.
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References
Rosenberg, B., VanCamp, L., Trosko, J. E., and Mansour, V. H., Nature, 222, 385 (1969).
Rosenberg, B., and VanCamp, L., Cancer Res., 30, 1799 (1970).
Leonard, B. J., in Proceedings, European Society for the Study of Drug Toxicity, 10, 183 (Oxford, 1968).
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LEONARD, B., ECCLESTON, E., JONES, D. et al. Antileukaemic and Nephrotoxic Properties of Platinum Compounds. Nature 234, 43–45 (1971). https://doi.org/10.1038/234043a0
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DOI: https://doi.org/10.1038/234043a0
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