Abstract
L-ASPARAGINASE, widely regarded as a potential oncolytic agent1–6, is known to depress both cellular and humoral immunity. Our investigation of the effect of L-asparaginase on the complement system, described in what follows, reveals a more complicated interaction—the enzyme inhibits the complement in whole serum in vitro but is a potent activator of the same system in certain circumstances.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Broome, J. D., Nature, 191, 1114 (1961).
Astaldi, G., Burgeo, G. R., Krc, J., Genova, R., and Astaldi, jun., A., Lancet, i, 423 (1969).
Ohno, R., Proc. Amer. Assoc. Cancer Res., 10, 66 (1969).
Schwartz, R. S., Nature, 224, 275 (1969).
Ohno, R., and Hersh, E. M., Blood, 35, 250 (1970).
Ohno, R., and Hersh, E. M., Cancer Res., 30, 1605 (1970).
Mayer, M. M., in Experimental Immunochemistry (edit. by Kabat, E. A., and Mayer, M. M.) (Thomas, Springfield, Illinois, 1961).
Leon, M. A., J. Exp. Med., 105, 403 (1957).
Gigli, I., and Austen, K. F., J. Exp. Med., 129, 679 (1969).
Pickering, R. J., Naff, G. R., Stroud, R. M., Good, R. A., and Gewurz, H., J. Exp. Med., 131, 803 (1970).
Haines, A. L., and Lepow, I. H., J. Immunol., 92, 468 (1964).
Lepow, I. H., Ratnoff, O. D., Rosen, F. S., and Pillemer, L., Proc. Soc. Exp. Biol. Med., 92, 32 (1956).
Donaldson, V., and Rosen, F. S., J. Clin. Invest., 43, 2204 (1964).
Oettgen, H. F., Stephenson, P. A., Schwartz, M. K., Leeper, R. D., Tallal, L., Tan, C. C., Clarkson, B. D., Golbey, R. B., Krakoff, I. H., Karnofsky, D. A., Murphy, M. L., and Burchenal, J. H., Cancer, 25, 253 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DELAGE, J., SIMARD, J., LEHNER-NETSCH, G. et al. L-Asparaginase and Complement. Nature 233, 485–486 (1971). https://doi.org/10.1038/233485a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/233485a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
