Abstract
I HAVE used a sterically based hypothesis of the mode of action of aryl insecticides, including DDT1, to predict possible structures of new compounds, the synthesis2 of which has been directed at finding insecticides with low mammalian toxicity and which, because of their inherent chemical instability, would readily degrade. Insecticidal activity has been studied in susceptible and resistant housefly and investigations have been made of acute mammalian toxicity and chemical in vitro degradation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Holan, G., Nature, 221, 1025 (1969).
C.S.I.R.O., Australian Patent Applications Nos. 33896/68, 40743/68, 40745/68, PA 1945/70, PA 2367/70.
Narahashi, T., and Haas, H. G., J. Gen. Physiol., 51, 177 (1968).
Rogers, E. F., Brown, H. D., Rasmussen, I. M., and Heal, R. E., J. Amer. Chem. Soc., 75, 2991 (1953).
Skerrett, E. J., and Woodcock, D., J. Chem. Soc., 2718 (1950).
Hass, H. B., Neher, M. B., and Blickenstaff, R. T., Ind. Eng. Chem., 43, 2875 (1951).
Jacob, T. A., Bachman, G. B., and Hass, H. B., J. Org. Chem., 16, 1572 (1951).
Agosin, M., Michaeli, D., Miskus, R., Nagasawa, S., and Hoskins, W. M., J. Econ. Entomol., 54, 340 (1961).
Stritmatter, P., in Biological Oxidations (edit. by Singer, T. P.), 171 (Interscience, New York, 1968).
Wilkinson, C. F., World Review of Pest Control, 7, 155 (1968).
Tsukamoto, M., Botyu Kagaku, 25, 156 (1960).
Margerum, J. D., Pitts, jun., J. N., Rutgers, J. G., and Searles, S., J. Amer. Chem. Soc., 81, 1549 (1959).
Arnold, D. R., in Adv. in Photochem. (edit. by Noyes, jun., W. A., Hammond, G. S., and Pitts, jun., J. N.), 7, 340 (Interscience, New York, 1968).
Holan, G., Bull. Wld. Health Org. (in the press).
Lipke, H., and Kearns, C. W., Advan. Pest Control Res., 3, 253 (1960).
Plapp, jun., J. N., in Biochemical Toxicology of Insecticides (edit. by O'Brien, R. D., and Yamamoto, I.), 179 (Academic Press, New York, 1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HOLAN, G. Rational Design of Degradable Insecticides. Nature 232, 644–647 (1971). https://doi.org/10.1038/232644b0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/232644b0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
