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Role of Reduced TPN in the Response to Interstitial Cell Stimulating Hormone

Nature volume 232, pages 631–632 (1971)Cite this article

Abstract

DISCUSSING the mechanism of action of interstitial cell stimulating hormone (ICSH), also called luteinizing hormone, on the ovary, Flint and Denton1 concluded that the “primary steroidogenic response” of rat lutein tissue to ICSH involves no change in the cytoplasmic concentration of TPNH (NADPH). This argument was based on two observations: (i) glucose added in vitro to luteal tissue increased TPNH/TPN+ but not steroid synthesis and (ii) ICSH in vivo increased steroid synthesis but not TPNH/TPN+. Steroid synthesis was observed to increase by 0.19 µmol/g/h after injection of ICSH. The interpretation proposed reveals a fundamental misunderstanding of the significance of steady state values of TPNH/TPN+ which this letter attempts to clarify.

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Authors and Affiliations

  1. Department of Biochemistry, University of Melbourne, Parkville, Victoria

    PETER F. HALL

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  1. PETER F. HALL
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HALL, P. Role of Reduced TPN in the Response to Interstitial Cell Stimulating Hormone. Nature 232, 631–632 (1971). https://doi.org/10.1038/232631b0

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  • DOI: https://doi.org/10.1038/232631b0

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