Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Para-nucleolar Position of the Human Y Chromosome in Interphase Nuclei

Abstract

INDIVIDUAL human chromosomes cannot be seen during interphase, and little is known of their intra-nuclear position during most of the cell cycle. The principal exception to this has been the X chromosomes: when there is more than one, they condense during interphase to form the sex chromatin, which is often located on the nuclear membrane. It has recently become possible to locate the major portion of the Y chromosome in interphase nuclei1, and we have used this technique to demonstrate that the Y chromosome is spatially associated with the nucleolus.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Pearson, P. L., Bobrow, M., and Vosa, C. G., Nature, 226, 78 (1970).

    Article  ADS  CAS  Google Scholar 

  2. Busch, H., and Smetana, K., The Nucleolus (Academic Press, New York, 1970).

    Google Scholar 

  3. Court Brown, W. M., Human Population Cytogenetics (North-Holland, Amsterdam, 1967).

    Google Scholar 

  4. Gripenberg, U., Chromosoma, 15, 618 (1964).

    Article  CAS  Google Scholar 

  5. Ferguson-Smith, M. A., and Handmaker, S. D., Ann. Hum. Genet., 27, 143 (1963).

    Article  CAS  Google Scholar 

  6. Ferguson-Smith, M. A., Cytogenetics, 3, 124 (1964).

    Article  CAS  Google Scholar 

  7. Arrighi, F. E., and Hsu, T. C., Cytogenetics (in the press).

  8. Hsu, T. C., Brinkley, B. R., and Arrighi, F. E., Chromosoma, 23, 137 (1967).

    Article  CAS  Google Scholar 

  9. Bobrow, M., Pearson, P. L., Pike, M. C., and El-Alfi, O. S., Cytogenetics (in the press).

  10. Borgaonkar, D. S., and Hollander, D. H., Nature, 230, 52 (1971).

    Article  ADS  CAS  Google Scholar 

  11. Ferguson-Smith, M. A., Bull. Europ. Soc. Hum. Genet., 4, 39 (1970).

    Google Scholar 

  12. Pearson, P. L., Bobrow, M., Vosa, C. G., and Barlow, P. W., Nature, 231, 326 (1971).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

BOBROW, M., PEARSON, P. & COLLACOTT, H. Para-nucleolar Position of the Human Y Chromosome in Interphase Nuclei. Nature 232, 556–557 (1971). https://doi.org/10.1038/232556a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/232556a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing