Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

LSD-25 Does Not Intercalate in DNA

Nature volume 232, pages 191–192 (1971)Cite this article

Abstract

APART from its hallucinogenic effect, lysergic acid diethylamide (LSD-25) is believed to cause chromosome abnormalities1–3, which have been attributed to a direct interaction of the LSD-25 and DNA4. The apparent resemblance of the circular dichroism spectra of the DNA–ethidium-bromide complex and mixtures of LSD-25 and DNA has led to the suggestion that LSD-25 might be intercalated in the DNA5.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Cohen, M. M., Marinello, I., and Bach, N., Science, 155, 1417 (1967).

    Article  ADS  CAS  Google Scholar 

  2. Irwin, S., and Egozine, J., Science, 157, 313 (1967).

    Article  ADS  CAS  Google Scholar 

  3. Bick, Y. A. E., Nature, 226, 1165 (1970).

    Article  ADS  CAS  Google Scholar 

  4. Yielding, K. L., and Sterglanz, H., Proc. Soc. Exp. Biol. Med., 128, 1096 (1968).

    Article  CAS  Google Scholar 

  5. Wagner, T. E., Nature, 222, 1170 (1969).

    Article  ADS  CAS  Google Scholar 

  6. Crawford, L. V., and Waring, M. J., J. Mol. Biol., 25, 23 (1967).

    Article  CAS  Google Scholar 

  7. Waring, M. J., Nature, 219, 1320 (1968).

    Article  ADS  CAS  Google Scholar 

  8. Ruttenberg, G. J. C. M., Smit, E. M., Borst, P., and Van Bruggen, E. F. J., Biochim. Biophys. Acta, 157, 429 (1968).

    Article  CAS  Google Scholar 

  9. Bauer, W., and Vinograd, J., J. Mol Biol., 33, 141 (1968).

    Article  CAS  Google Scholar 

  10. Zimm, B. H., and Crothers, P. M., Proc. US Nat. Acad. Sci., 48, 905 (1961).

    Article  ADS  Google Scholar 

  11. Espejo, R. T., and Canelo, E. S., Virology, 34, 738 (1968).

    Article  CAS  Google Scholar 

  12. Espejo, R. T., Canelo, E. S., and Sinsheimer, R. L., Proc. US Nat. Acad. Sci., 63, 1164 (1969).

    Article  ADS  CAS  Google Scholar 

  13. Vendrely, R., in The Nucleic Acids (edit. by Chargaff, E., and Davidson, J. N.), 2, 155 (Academic Press, New York, 1955).

    Google Scholar 

  14. Papirmeister, B., and Wolpert, J. S., Biochem. Biophys. Res. Commun., 38, 319 (1970).

    Article  CAS  Google Scholar 

  15. Smit, E. M., and Borst, P., FEBS Lett., 14, 125 (1971).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Biochemistry, Department of Medical Enzymology, University of Amsterdam,

    E. M. SMIT & P. BORST

Authors
  1. E. M. SMIT
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. BORST
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

SMIT, E., BORST, P. LSD-25 Does Not Intercalate in DNA. Nature 232, 191–192 (1971). https://doi.org/10.1038/232191a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/232191a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing