Abstract
SEVERAL investigators have already shown that electrical stimulation of the mid-brain raphé, in which neuronal perikarya containing 5-hydroxytryptamine (serotonin) are almost exclusively located1, produces a significant increase in the forebrain content of 5-hydroxyindolyl-3-acetic acid (5-HIAA), while the concentration of serotonin decreased or remained unchanged2–6. This communication describes how N,N-dimethyltryptamine (DMT) and D-lysergic acid diethylamide (LSD), the two potent psychotogenic drugs, affect the release of serotonin and 5-HIAA in the forebrain when the mid-brain is stimulated. Both drugs uniformly inhibit the response of single units in the mid-brain raphé nuclei7,8.
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RANDIĆ, M., PADJEN, A. Effect of N,N-Dimethyltryptamine and D-Lysergic Acid Diethylamide on the Release of 5-Hydroxyindoles in Rat Forebrain. Nature 230, 532–533 (1971). https://doi.org/10.1038/230532a0
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DOI: https://doi.org/10.1038/230532a0
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