Abstract
So far it has not been possible to distinguish experimentally between two possible models for cooperative ligand binding by haemoglobin. Numerical analysis, however, yields a unique value for the allosteric constant showing that only the two state model can account for the behaviour of the protein.
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EDELSTEIN, S. Extensions of the Allosteric Model for Haemoglobin. Nature 230, 224–227 (1971). https://doi.org/10.1038/230224a0
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DOI: https://doi.org/10.1038/230224a0
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