Abstract
Kinetic studies of the denaturation and renaturation of proteins indicate metastable intermediates which are not on the direct pathway between native and denatured states. This suggests that the initial steps in the folding of a structureless polypeptide chain may often be rapidly reversed and without influence on the ultimate result.
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References
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IKAI, A., TANFORD, C. Kinetic Evidence for Incorrectly Folded Intermediate States in the Refolding of Denatured Proteins. Nature 230, 100–102 (1971). https://doi.org/10.1038/230100a0
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DOI: https://doi.org/10.1038/230100a0
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