Abstract
Mutants of E. coli, deficient in DNA polymerase activity in vitro, spontaneously generate chromosomal deletions at a high frequency. Such deletions may arise from the inability of these strains to repair single-strand breaks in DNA efficiently.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Spudich, J. A., Horn, V., and Yanofsky, C., J. Mol. Biol. (in the press).
Coukell, M. B., and Yanofsky, C., Genetics (in the press).
De Lucia, P., and Cairns, J., Nature, 224, 1164 (1969).
Gross, J. D., and Gross, M., Nature, 224, 1166 (1969).
Kornberg, A., Science, 163, 1410 (1969).
Kelly, R. B., Atkinson, M. R., Huberman, J. A., and Kornberg, A., Nature, 224, 495 (1969).
Yanofsky, C., Ito, J., and Horn, V., Cold Spring Harbor Symp. Quant. Biol., 31, 151 (1966).
Setlow, R. B., and Carrier, W. L., Proc. US Nat. Acad. Sci., 51, 226 (1964).
Boyce, R. P., and Howard-Flanders, P., Proc. US Nat. Acad. Sci., 51, 293 (1964).
Pettijohn, D. E., and Hanawalt, P. C., J. Mol. Biol., 9, 395 (1964).
McGrath, R. A., and Williams, R. W., Nature, 212, 534 (1966).
Gellert, M., Proc. US Nat. Acad. Sci., 57, 148 (1967).
Olivera, B. M., and Lehman, I. R., Proc. US Nat. Acad. Sci., 57, 1426 (1967).
Howard-Flanders, P., Boyce, R. P., and Theriot, L., Genetics, 53, 1119 (1966).
Ogawa, H., Shimada, K., and Tomizawa, J., Molec. Gen. Genet., 101, 227 (1968).
Walker, J. R., J. Bact., 99, 713 (1969).
Franklin, N. C., Genetics, 55, 699 (1967).
Inselburg, J., J. Bact., 94, 1266 (1967).
Anderson, C. W., Mutation Res., 9, 155 (1970).
Kanner, L., and Hanawalt, P., Biochem. Biophys. Res. Commun., 39, 149 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
COUKELL, M., YANOFSKY, C. Increased Frequency of Deletions in DNA Polymerase Mutants of Escherichia coli. Nature 228, 633–635 (1970). https://doi.org/10.1038/228633a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/228633a0
This article is cited by
-
Role of the 5´ → 3´ exonuclease and Klenow fragment of Escherichia coli DNA polymerase I in base mismatch repair
Molecular Genetics and Genomics (2007)
-
A new mutation inEscherichia coli K12,isfA, which is responsible for inhibition of SOS functions
Molecular and General Genetics MGG (1995)
-
DNA sequence analysis of spontaneous histidine mutations in a polA1 strain of Escherichia coli K12 suggests a specific role of the GTGG sequence
Molecular and General Genetics MGG (1990)
-
DNA sequence analysis of spontaneous mutation in a PolA1 strain of Escherichia coli indicates sequence-specific effects
Molecular and General Genetics MGG (1987)
-
DNA polymerase III-dependent repair synthesis in response to bleomycin in toluene-treated Escherichia coli
Molecular and General Genetics MGG (1980)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.