Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Increased Frequency of Deletions in DNA Polymerase Mutants of Escherichia coli

Abstract

Mutants of E. coli, deficient in DNA polymerase activity in vitro, spontaneously generate chromosomal deletions at a high frequency. Such deletions may arise from the inability of these strains to repair single-strand breaks in DNA efficiently.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Spudich, J. A., Horn, V., and Yanofsky, C., J. Mol. Biol. (in the press).

  2. Coukell, M. B., and Yanofsky, C., Genetics (in the press).

  3. De Lucia, P., and Cairns, J., Nature, 224, 1164 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Gross, J. D., and Gross, M., Nature, 224, 1166 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Kornberg, A., Science, 163, 1410 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Kelly, R. B., Atkinson, M. R., Huberman, J. A., and Kornberg, A., Nature, 224, 495 (1969).

    Article  ADS  CAS  Google Scholar 

  7. Yanofsky, C., Ito, J., and Horn, V., Cold Spring Harbor Symp. Quant. Biol., 31, 151 (1966).

    Article  CAS  PubMed  Google Scholar 

  8. Setlow, R. B., and Carrier, W. L., Proc. US Nat. Acad. Sci., 51, 226 (1964).

    Article  ADS  CAS  Google Scholar 

  9. Boyce, R. P., and Howard-Flanders, P., Proc. US Nat. Acad. Sci., 51, 293 (1964).

    Article  ADS  CAS  Google Scholar 

  10. Pettijohn, D. E., and Hanawalt, P. C., J. Mol. Biol., 9, 395 (1964).

    Article  CAS  PubMed  Google Scholar 

  11. McGrath, R. A., and Williams, R. W., Nature, 212, 534 (1966).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Gellert, M., Proc. US Nat. Acad. Sci., 57, 148 (1967).

    Article  ADS  CAS  Google Scholar 

  13. Olivera, B. M., and Lehman, I. R., Proc. US Nat. Acad. Sci., 57, 1426 (1967).

    Article  ADS  CAS  Google Scholar 

  14. Howard-Flanders, P., Boyce, R. P., and Theriot, L., Genetics, 53, 1119 (1966).

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Ogawa, H., Shimada, K., and Tomizawa, J., Molec. Gen. Genet., 101, 227 (1968).

    Article  CAS  PubMed  Google Scholar 

  16. Walker, J. R., J. Bact., 99, 713 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Franklin, N. C., Genetics, 55, 699 (1967).

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Inselburg, J., J. Bact., 94, 1266 (1967).

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Anderson, C. W., Mutation Res., 9, 155 (1970).

    Article  CAS  PubMed  Google Scholar 

  20. Kanner, L., and Hanawalt, P., Biochem. Biophys. Res. Commun., 39, 149 (1970).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

COUKELL, M., YANOFSKY, C. Increased Frequency of Deletions in DNA Polymerase Mutants of Escherichia coli. Nature 228, 633–635 (1970). https://doi.org/10.1038/228633a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/228633a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing