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Synthetic DNA–RNA Hybrids and RNA–RNA Duplexes as Templates for the Polymerases of the Oncogenic RNA Viruses

An Erratum to this article was published on 07 November 1970

Abstract

Six RNA viruses have now been shown to contain DNA polymerase activities directed by single-stranded RNA, double-stranded RNA and double-stranded DNA. It is further demonstrated that DNA–RNA hybrids, such as synthetic dC.rG, act as even more effective templates.

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References

  1. Temin, H. M., and Mizutani, S., Nature, 226, 1211 (1970).

    Article  ADS  CAS  Google Scholar 

  2. Baltimore, D., Nature, 226, 1209 (1970).

    Article  ADS  CAS  Google Scholar 

  3. Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Trávníček, M., and Watson, K., Nature, 227, 563 (1970).

    Article  ADS  CAS  Google Scholar 

  4. Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Trávníček, M., and Watson, K., Nature, 227, 1029 (1970).

    Article  ADS  CAS  Google Scholar 

  5. Kornberg, A., Enzymatic Synthesis of DNA, 103 (Wiley, New York and London, 1961).

    Google Scholar 

  6. Eikhom, T. S., and Spiegelman, S., Proc. US Nat. Acad. Sci., 57, 1832 (1964).

    Google Scholar 

  7. Fox, C. F., Robinson, W. S., Haselkorn, R., and Weiss, S. B., J. Biol. Chem., 239, 186 (1964).

    CAS  Google Scholar 

  8. Lee-Huang, S., and Cavalieri, L. F., Proc. US Nat Acad. Sci., 51, 1022 (1964).

    Article  ADS  CAS  Google Scholar 

  9. Chopra, H. C., Bogden, A. E., Zelljadt, J., and Jensen, C. M., Europ. J. Cancer (in the press).

  10. Gillespie, D., and Spiegelman, S., J. Mol. Biol., 12, 829 (1965).

    Article  CAS  Google Scholar 

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SPIEGELMAN, S., BURNY, A., DAS, M. et al. Synthetic DNA–RNA Hybrids and RNA–RNA Duplexes as Templates for the Polymerases of the Oncogenic RNA Viruses. Nature 228, 430–432 (1970). https://doi.org/10.1038/228430a0

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