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Increased Recovery of Anaesthetized Hypothermic Rats induced by Intracarotid Infusion

Abstract

WE have shown previously that if rats were cooled to cardiac arrest without assisted ventilation, held thus for 30 min, and rewarmed with artificial ventilation, only 9 per cent of them recovered1,2. This incidence could be increased to 45 per cent if their abdomens were pumped before rewarming3,4. In these experiments, if the abdominal pumping had failed to restart the heart, spontaneous respiration did not subsequently recover. We now report new measures which further increased the incidence both of the hearts restarting and the recovery of spontaneous respiration.

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References

  1. Hillman, H., and Rogers, P., J. Physiol., 204, 87 (1969).

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  2. Niazi, S. A., and Lewis, F. J., Surgery, 36, 25 (1954).

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  3. Rogers, P., and Hillman, H., J. Appl. Physiol., 29, 58 (1970).

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  4. Rogers, P., J. Physiol., 207, 19 (1970).

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ROGERS, P., HILLMAN, H. Increased Recovery of Anaesthetized Hypothermic Rats induced by Intracarotid Infusion. Nature 228, 1314–1315 (1970). https://doi.org/10.1038/2281314b0

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  • DOI: https://doi.org/10.1038/2281314b0

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