Abstract
THE aggregation of phagocytic cells at inflammatory sites is a characteristic feature of the defence of multicellular organisms against potentially injurious agents1–4. From the point of view of comparative immunity, it is the one clear-cut similarity between vertebrates and invertebrates. Although multiple mechanisms may exist which control the accumulation of these cells, the obvious biological importance of this common defence system suggests the conservation of its principal elements in evolution. We have investigated the effects of macrophage-active factors from an invertebrate source on vertebrate (mammalian) inflammatory mechanisms.
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PRENDERGAST, R., SUZUKI, M. Invertebrate Protein Simulating Mediators of Delayed Hypersensitivity. Nature 227, 277–279 (1970). https://doi.org/10.1038/227277a0
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DOI: https://doi.org/10.1038/227277a0
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