Abstract
THE thymus plays an important part in the development of certain immune reactions. Neonatally thymectomized mice showed an impaired antibody response to heterologous erythrocytes and serum proteins1. Recent studies, have demonstrated that collaboration between thymus-derived cells and bone marrow-derived cells was essential for mice to respond to sheep red blood cells (SRBC) by producing haemolysin-forming cells2–4. Thymus-derived cells, although undergoing mitosis in response to the antigenic stimulus5, did not produce antibody6, but influenced bone marrow-derived precursor cells to differentiate into antibody-producing cells4.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Miller, J. F. A. P., and Osoba, D., Physiol. Rev., 47, 437 (1967).
Claman, H. N., Chaperon, E. A., and Triplett, R. F., Proc. Soc. Exp. Biol. Med., 122, 1167 (1966).
Miller, J. F. A. P., and Mitchell, G. F., J. Exp. Med., 128, 801 (1968).
Mitchell, G. F., and Miller, J. F. A. P., J. Exp. Med., 128, 821 (1968).
Davies, A. J. S., Leuchars, E., Wallis, V., and Koller, P. C., Transplantation, 4, 438 (1966).
Davies, A. J. S., Leuchars, E., Wallis, V., Marchant, R., and Elliott, E. V., Transplantation, 5, 222 (1967).
Brunner, K. T., Mauel, J., Cerottini, J.-C., and Chapuis, B., Immunology, 14, 181 (1967).
Brunner, K. T., Mauel, J., Rudolf, H., and Chapuis, B., Immunology (in the press).
Martin, W. J., J. Immunol., 103, 979 (1969).
Billingham, R. E., Ann. NY Acad. Sci., 73, 782 (1958).
Vos, O., de Vries, J., Collenteur, J. C., and van Bekkum, D. W., J. Nat. Cancer Inst., 23, 53 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CEROTTINI, JC., NORDIN, A. & BRUNNER, K. In vitro Cytotoxic Activity of Thymus Cells sensitized to Alloantigens. Nature 227, 72–73 (1970). https://doi.org/10.1038/227072a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/227072a0
This article is cited by
-
Modulation of allo-immune responsesin vivo andin vitro by sperm specific lactate dehydrogenase-C4
Molecular and Cellular Biochemistry (1993)
-
Studies on experimental ancylostomiasis: Transfer of acquired immunity toAncylostoma caninum in mice through sensitized thymus and bone marrow cells
Experientia (1979)
-
Ultrastructure of rosette-forming cells in the wall of an intestinal allograft
Bulletin of Experimental Biology and Medicine (1979)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
