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Release Factor Translation of RNA Phage Terminator Codons

Nature volume 227, pages 38–40 (1970)Cite this article

Abstract

Release factors R1 or R2 stimulate equally well the release of f2 coat protein, suggesting that UAA is the first coat terminator codon. The suppression of a nonsense codon can be regulated in vitro by the concentration of R factor of appropriate codon specificity.

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References

  1. Capecchi, M. R., Proc. US Nat. Acad. Sci., 58, 1144 (1967).

    Article  ADS  CAS  Google Scholar 

  2. Caskey, C. T., Tompkins, R., Scolnick, E., Caryk, T., and Nirenberg, M., Science, 162, 135 (1958).

    Article  ADS  Google Scholar 

  3. Last, J. A., Stanley, W. M., Salas, M., Hille, M. B., Wahba, A. J., and Ochoa, S., Proc. US Nat. Acad. Sci., 57, 1062 (1967).

    Article  ADS  CAS  Google Scholar 

  4. Scolnick, E., Tompkins, R., Caskey, T., and Nirenberg, M., Proc. US Acad. Sci., 61, 768 (1968).

    Article  ADS  CAS  Google Scholar 

  5. Scolnick, E. M., and Caskey, C. T., Proc. US Nat. Acad. Sci., 64, 1235 (1969).

    Article  ADS  CAS  Google Scholar 

  6. Caskey, T., Scolnick, E., Tompkins, R., Goldstein, J., and Milman, G., Cold Spring Harbor Symp. Quant. Biol., 34, 479 (1969).

    Article  CAS  Google Scholar 

  7. Capecchi, M. R., and Klein, H. A., Cold Spring Harbor Symp. Quant. Biol., 34, 469 (1969).

    Article  CAS  Google Scholar 

  8. Beaudet, A., Goldstein, J., Milman, G., Tompkins, R., Rosman, M., Scolnick, E., and Caskey, C. T., Fed. Proc., 29, 583 (1970) (Abst.).

    Google Scholar 

  9. Nichols, J. L., Nature, 225, 147 (1970).

    Article  ADS  CAS  Google Scholar 

  10. Nathans, D., J. Mol. Biol., 13, 521 (1965).

    Article  CAS  Google Scholar 

  11. Weber, K., and Konigsberg, W., J. Biol. Chem., 242, 8563 (1967).

    Google Scholar 

  12. Ganoza, M. C., and Nakamoto, T., Proc. US Nat. Acad. Sci., 55, 162 (1966).

    Article  ADS  CAS  Google Scholar 

  13. Cuzin, F., Kretchmer, N., Greenberg, R. E., Hurwitz, R., and Chapeville, F., Proc. US Nat. Acad. Sci., 58, 2079 (1967).

    Article  ADS  CAS  Google Scholar 

  14. Webster, R. E., Engelhardt, D. L., Zinder, N. D., and Konigsberg, W., J. Mol. Biol., 29, 27 (1967).

    Article  CAS  Google Scholar 

  15. Roufa, D. J., Doctor, B. P., and Leder, P., Biochem. Biophys. Res. Commun. (in the press).

  16. Rechler, M., and Martin, R. G., Nature, 226, 908 (1970).

    Article  ADS  CAS  Google Scholar 

  17. Webster, R. E., and Zinder, N. D., J. Mol. Biol., 42, 425 (1969).

    Article  CAS  Google Scholar 

  18. Newton, W. A., Beckwith, J. R., Zipser, D., and Brenner, S., J. Mol. Biol., 14, 290 (1965).

    Article  CAS  Google Scholar 

  19. Yanofsky, C., and Ito, J., J. Mol. Biol., 21, 313 (1966).

    Article  CAS  Google Scholar 

  20. Martin, R. G., Silbert, D. F., Smith, W. E., and Whitfield, jun., H. J., J. Mol. Biol., 21, 357 (1966).

    Article  CAS  Google Scholar 

  21. Engelhardt, D. L., Webster, R. E., Wilhelm, R. C., and Zinder, N. D., Proc. US Nat. Acad. Sci., 54, 1791 (1965).

    Article  ADS  CAS  Google Scholar 

  22. Gopinathan, K. P., and Garen, A., J. Mol. Biol., 47, 383 (1970).

    Article  Google Scholar 

  23. Milman, G., Goldstein, J., Scolnick, E., and Caskey, T., Proc. US Nat. Acad. Sci., 63, 183 (1969).

    Article  ADS  CAS  Google Scholar 

  24. Nirenberg, M. W., and Matthaei, J. H., Proc. US Nat. Acad. Sci., 47, 1588 (1961).

    Article  ADS  CAS  Google Scholar 

  25. Muench, K. H., and Berg, P., in Procedures in Nucleic Acid Research, 375 (Harper and Row, New York, 1966).

    Google Scholar 

  26. Vogel, Z., Zamir, A., and Elson, D., Biochemistry, 8, 5161 (1969).

    Article  CAS  Google Scholar 

  27. Chae, Y., Mazumder, R., and Ochoa, S., Proc. US Nat. Acad. Sci., 62, 1181 (1969).

    Article  ADS  CAS  Google Scholar 

  28. Vinuela, E., Algranati, I. D., and Ochoa, S., Europ. J. Biochem., 1, 3 (1967).

    Article  CAS  Google Scholar 

  29. Fromageot, H. P. M., and Zinder, N. D., Proc. US Nat. Acad. Sci., 61, 184 (1968).

    Article  ADS  CAS  Google Scholar 

  30. Garen, A., Garen, S., and Wilhelm, R., J. Mol. Biol., 14, 167 (1965).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Section of Medical Genetics, Laboratory of Biochemical Genetics, National Heart and Lung Institute, US National Institutes of Health, Bethesda, Maryland, 20014

    ARTHUR L. BEAUDET & C. THOMAS CASKEY

Authors
  1. ARTHUR L. BEAUDET
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  2. C. THOMAS CASKEY
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BEAUDET, A., CASKEY, C. Release Factor Translation of RNA Phage Terminator Codons. Nature 227, 38–40 (1970). https://doi.org/10.1038/227038a0

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