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Characterization of Ovine Hypothalamic Hypophysiotropic TSH-releasing Factor

Nature volume 226, pages 321–325 (1970)Cite this article

An Erratum to this article was published on 02 May 1970

Abstract

Evidence is presented for the homogeneity of a preparation of hypothalamic TRF of ovine origin and its molecular structure has been established as 2-pyrrolidone-5-carboxylyl-histidyl-proline amide. Synthetic L-2-pyrrolidone-5-carboxylyl-L-histidyl-L-proline amide has physicochemical and biological characteristics which are quantitatively and qualitatively indistinguishable from those of the natural substance isolated in this laboratory.

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Author notes

  1. DOMINIC DESIDERIO: Lipid Research Institute, Baylor College of Medicine, Houston.

  2. DARRELL N. WARD: Department of Biochemistry, University of Texas M. D. Anderson Hospital and Tumor Institute, Houston.

Authors and Affiliations

  1. Department of Physiology, Baylor College of Medicine, Houston, Texas, 77025

    ROGER BURGUS, THOMAS F. DUNN, DOMINIC DESIDERIO, DARRELL N. WARD, WYLIE VALE & ROGER GUILLEMIN

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  1. ROGER BURGUS
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  2. THOMAS F. DUNN
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  3. DOMINIC DESIDERIO
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  4. DARRELL N. WARD
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  5. WYLIE VALE
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  6. ROGER GUILLEMIN
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BURGUS, R., DUNN, T., DESIDERIO, D. et al. Characterization of Ovine Hypothalamic Hypophysiotropic TSH-releasing Factor. Nature 226, 321–325 (1970). https://doi.org/10.1038/226321a0

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