Abstract
IN 1966, Geering, Old and Boyse1 identified group-specific (gs) antigens of murine leukaemia viruses (MuLV) in immunoprecipitation tests with antigen in the form of disrupted virions or extracts of infected tissue. Antisera containing a wide range of precipitating MuLV antibodies are obtained from inbred rats bearing large subcutaneous transplants of syngeneic leukaemias induced by wild-type Gross virus1. Usually a large number of rats have to be screened in order to find one with antibody to the complete set of MuLV antigens known to be demonstrable by immunoprecipitation. Rats which have both a massive local tumour and metastasis to local lymph nodes, and which have survived for a comparatively long time after they received the leukaemic transplants, are most likely to yield such antisera.
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GEERING, G., AOKI, T. & OLD, L. Shared Viral Antigen of Mammalian Leukaemia Viruses. Nature 226, 265–266 (1970). https://doi.org/10.1038/226265a0
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DOI: https://doi.org/10.1038/226265a0
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